The Science Behind The Sleep

Ready to delve into the science behind Sleepee?

All 11 ingredients in our Sleepee supplement have been selected based on extensive scientific research which supports their efficacy, and all at their optimum dosages. Rigorous studies have confirmed the effectiveness of these miracle ingredients, and we’ve put them all into one game-changing formula to help give you deep, restful sleep, night after night.

1. Montmorency Cherry: Montmorency cherries are rich in natural melatonin, the hormone that regulates the sleep-wake cycle. A study published in the European Journal of Nutrition [1] found that consuming tart cherry juice significantly increased melatonin levels and improved sleep duration and quality in adults suffering from insomnia. Another study also found that it increased sleep time and sleep efficiency [2]. Sleepee contains the equivalent of an impressive 5000mg of montmorency cherry extract (many of our competitors' supplements only contain 300mg of extract at most) to boost your body’s melatonin levels.

2. Magnesium Oxide: Numerous studies suggest that magnesium deficiency may negatively affect sleep duration and quality, so increasing magnesium levels in the body with magnesium oxide can help improve your sleep. Magnesium is an essential mineral involved in numerous bodily functions, including sleep regulation, and research published in the Journal of Research in Medical Sciences [3] demonstrated that magnesium supplementation improved sleep efficiency, sleep time, and sleep onset latency in elderly individuals with insomnia. A huge study [4] of over 5,000 Americans also found that magnesium intake was associated with higher sleep quality and longer sleep duration.

3. L-Tryptophan: L-Tryptophan is an amino acid that serves as a precursor to both serotonin and melatonin. A meta-analysis published in the Journal of Psychiatric Research [5] concluded that L-Tryptophan supplementation significantly reduced sleep latency and improved sleep quality.

4. Vitamin B6: Vitamin B6 is involved in the synthesis of neurotransmitters, including serotonin and melatonin. A study published in the Journal of Sleep Research [6] found that Vitamin B6 supplementation improved sleep quality and reduced insomnia symptoms in participants with poor sleep.

5. Zinc: Zinc is a mineral that plays a crucial role in various biological processes, including sleep regulation. A study published in the Journal of Sleep Research revealed that zinc supplementation improved sleep quality and efficiency in individuals with insomnia. [7]

6. Biotin: Biotin, also known as Vitamin B7, is involved in the metabolism of neurotransmitters and the regulation of sleep. Although direct evidence linking biotin to sleep is limited, maintaining adequate levels of biotin with the small dose in Sleepee is essential for overall health, including stabilising mood, and may indirectly contribute to better sleep.

7. Passionflower: Passionflower, dubbed ‘nature’s sedative’, is an insomnia and anxiety-busting ingredient that’s making waves across the globe right now. Known for its calming properties, in numerous studies it has been shown to promote relaxation and improve sleep quality [8]. Research suggests that passionflower can increase levels of gamma-aminobutyric acid (GABA), a neurotransmitter that helps regulate mood and reduce anxiety. By enhancing GABA activity, passionflower can induce feelings of tranquillity and ease, making it easier to fall asleep and stay asleep throughout the night.

8. Glycine: Research suggests that glycine may help promote better sleep by modulating neurotransmitters and regulating body temperature. Studies have shown that glycine supplementation can lead to improvements in sleep onset latency, sleep efficiency, and overall sleep quality [9]. Glycine has also been found to have a calming effect on the brain, reducing anxiety and promoting relaxation, which can contribute to better sleep.

9. Chamomile Flower Extract: Chamomile flower extract, known for its calming properties, has been traditionally used as a remedy for sleep-related issues. Studies have shown that chamomile may help improve sleep quality by promoting relaxation and reducing anxiety, especially in older people [10]. The compounds found in chamomile, such as apigenin, bind to receptors in the brain that are associated with sleep regulation, leading to a sedative effect. Chamomile has also been shown to increase levels of glycine, mentioned above.

10. Lemon Balm Extract: The compounds in lemon balm, such as rosmarinic acid and flavonoids, have been shown to have sedative effects, helping to calm the nervous system and promote feelings of relaxation. Several studies suggest that lemon balm may have sleep-inducing properties, making it beneficial for those struggling with insomnia or poor sleep quality [11].

11. Lion’s Mane Mushroom: While lion's mane mushroom is primarily known for its cognitive benefits, some research suggests that it may also contribute to improved sleep quality [12]. Lion's mane may help reduce the time it takes to fall asleep, meaning we reach the REM stage faster. It may also help us stay in the REM sleep stage longer. Both of these things can help improve our overall quality of sleep. Lion's mane mushroom supports sound sleep even during periods of acute stress, according to a 2015 pilot study. Lion's mane contains compounds that support nerve growth and brain health, which can indirectly influence sleep by promoting overall well-being and reducing stress and anxiety. Additionally, lion's mane has been linked to enhanced mood and relaxation, factors that can contribute to better sleep patterns.

Scientific research validates the efficacy of Sleepee's 11 natural ingredients, demonstrating their ability to significantly improve sleep quality. Offering a natural solution, Sleepee can help you get your sleep pattern back on track, and wake up feeling refreshed instead of groggy. Experience the difference firsthand by trying it out today!

Sources:

1. https://pubmed.ncbi.nlm.nih.gov/22038497/
2. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5617749/
3. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3703169/
4. https://academic.oup.com/cdn/article/5/Supplement_2/1109/6292661
5. https://pubmed.ncbi.nlm.nih.gov/6764927/
6. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8155219/
7. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5713303/
8. https://pubmed.ncbi.nlm.nih.gov/21294203/
9. https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1479-8425.2007.00262.x
10. https://pubmed.ncbi.nlm.nih.gov/29154054/
11. https://www.nutraingredients.com/Article/2007/03/22/Berkem-builds-science-to-support-anti-stress-ingredient
12. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8643634